Jody Trapp led the way with 19 points, four assists, and six steals, while Ally Stamatiades added 14 points and Racquel Reid 12 points.
Baruch (18-3, 10-1 CUNYAC) opened the road game with a 21-5 run on their way to a 32-16 halftime lead.
John Jay (3-19, 2-8 CUNYAC) struggled from the field shooting 18-of-51, including 0-of-7 from three-point range.
Baruch will return to action this Monday night with a non-conference home game against Stevens Tech.
Tip off is scheduled for 7:00 p.m. in the ARC.